Authors:
Maryam Waqar1 , Fareeha Shahid2 , Ashok Kumar Tanwani3 , Ayesha Sarwar4 , Humera Javed5 , Maryam Zulfiqar6
1 Assistant Professor, Department of Pathology, HBS Medical & Dental College, Islamabad
2 Senior Lecturer, Department of Pathology, HBS Medical & Dental College, Islamabad
3 Professor, Department of Pathology, HBS Medical & Dental College, Islamabad
4 Associate Professor, Department of Pathology, HBS Medical & Dental College, Islamabad
5 Assistant Professor, Department of Pathology, HBS Medical & Dental College, Islamabad
6 Senior Lecturer, Department of Pathology, HBS Medical & Dental College, Islamabad
Revisions:
Received: Sep 19. 2023 Revised: Nov 13, 2023 Accepted: Dec 10. 2023 Published: Jan 05, 2024
DOI: https://doi.org/10.70394/jhbsmdc.v3i2.53
Abstract
Objectives: To study the histopathological spectrum of gallbladder diseases and compare the occurrence of gallbladder carcinoma in relation to age, gender and weight of the patient.
Methodology: This Cross-sectional study, retrospective study was conducted at Histopathology department of HBS General Hospital and Pakistan Institute of Medical Sciences (PIMS). Study was conducted over a period of 6 months from October 2021 to March 2022. Cholecystectomy specimens from either gender irrespective of their age received at the Histopathology Department of HBS General Hospital and Pakistan Institute of Medical Sciences (PIMS), over a period of 6 months were included in the study. The specimens were fixed in 10% formalin for 24 to 48 hours before sectioning. Then every specimen was macroscopically evaluated followed by cutting of the tissue into three representative sections, one each from the fundus, body and neck of the gallbladder along with the lymph nodes if provided. Hematoxylin & eosin staining was done & specimen. The clinical data from pathology reports and slides were retrieved from the archives and were microscopically examined by the histopathologists and the results were recorded.
Results: Mean age of the patients was 54.58 ±18.04 years. Females were more than the male patients. There were 315 (77.4%) female patients as compared to 92 (22.6%) male patients. The mean weight of the patients was 60.18 ±5.11 kg. The most common finding was chronic cholecystitis in 303 out of 407 total cases (85%) followed by acute cholecystitis in 27 cases (9.8%). There were 16 cases (3.9%) of incidental carcinoma and three cases (0.7%) of dysplasia.
Conclusion: A spectrum of histopathological diagnosis is observed in cholecystectomy specimen. The inflammatory gallbladder lesions are the most common pathology and the commonest diagnosis is chronic cholecystitis but the doctors cannot rely on the clinical or radiological diagnosis of gallbladder diseases. Histopathological analysis of all gallbladder specimens is necessary for the detection of carcinoma as the frequency of gallbladder cancer appears to be on the rise in our population which is significantly more common in females.
Keywords: Carcinoma, Gallbladder, Cholecystectomy specimens
